Do I need to start Dante Virtual Soundcard each time I wish to use it?

No. It is not necessary to turn Dante Virtual Soundcard off when you power off your computer. The Dante Virtual Soundcard application acts like a control panel, allowing the user to configure and enable the software. Dante Virtual Soundcard will show up as a soundcard in your audio settings. Once the application window is closed, Dante Virtual Soundcard continues to function and be available, even if the computer is restarted.More info